loading...| Preferred Name |
CD34 molecule |
| Synonyms |
hematopoietic progenitor cell antigen CD34 |
| Definitions |
是人CD34基因或其1:1直系同源物的翻译产物的蛋白质。它是由淋巴造血祖细胞特异性表达的白细胞膜蛋白。它包含一个单次跨膜结构域，并在早期造血前体和血管相关组织上显示出不同的表达。作为一个支架，它以成簇、组织特异性的方式呈现出选择素碳水化合物配体，以允许在炎症过程中白细胞和内皮细胞之间更高的亲合力相互作用。与相关的唾液黏蛋白（内切多糖和足细胞标记蛋白）一样，细胞外区域主要是由可被唾液酸化的O-连接碳水化合物密集取代的N-末端粘蛋白样结构域组成。粘蛋白样区域之后是一个含有半胱氨酸的球状结构域。该结构域可以折叠成免疫球蛋白样结构，因为2个半胱氨酸的位置在免疫球蛋白超家族的C2集中是保守的。细胞质结构域长约73-76个残基且高度保守。 A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved. |
| ID |
http://purl.obolibrary.org/obo/PR_000001003 |
| label |
CD34 molecule CD34 分子 |
| prefixIRI |
PR:000001003 |
| prefLabel |
CD34 molecule |
| textual definition |
是人CD34基因或其1:1直系同源物的翻译产物的蛋白质。它是由淋巴造血祖细胞特异性表达的白细胞膜蛋白。它包含一个单次跨膜结构域，并在早期造血前体和血管相关组织上显示出不同的表达。作为一个支架，它以成簇、组织特异性的方式呈现出选择素碳水化合物配体，以允许在炎症过程中白细胞和内皮细胞之间更高的亲合力相互作用。与相关的唾液黏蛋白（内切多糖和足细胞标记蛋白）一样，细胞外区域主要是由可被唾液酸化的O-连接碳水化合物密集取代的N-末端粘蛋白样结构域组成。粘蛋白样区域之后是一个含有半胱氨酸的球状结构域。该结构域可以折叠成免疫球蛋白样结构，因为2个半胱氨酸的位置在免疫球蛋白超家族的C2集中是保守的。细胞质结构域长约73-76个残基且高度保守。 A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved. |
| 引自 | |
| 有_精确的_同义词 |
hematopoietic progenitor cell antigen CD34 CD34 造血祖细胞抗原CD34 |
| subClassOf |