Ewings sarcoma

一种小的圆形细胞瘤，缺乏神经外胚层分化的形态学，免疫组织化学和电子显微镜证据。它代表被称为尤因氏肉瘤/周围神经外胚层肿瘤的光谱的两端之一。它主要影响20岁以下的男性，可以发生在软组织或骨骼中。最常见的临床症状是疼痛和肿块。 一系列恶性肿瘤主要影响20岁以下的男性，其形态特征为小圆形细胞的出现。 尤文氏肉瘤和外周原始神经外胚层肿瘤代表了光谱的末端，而尤文氏肉瘤缺乏神经分化的证据和表征外周原始神经外胚层肿瘤的标记。 尤文氏肉瘤和外周原始神经外胚层肿瘤可能同时存在细胞遗传学异常，原癌基因表达，细胞培养和免疫组化异常。 这些肿瘤可能发生在软组织或骨骼中。 疼痛和肿块是最常见的临床症状。 - 2004年 A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms. -- 2004 A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.

http://www.ebi.ac.uk/efo/EFO_0000174

一种小的圆形细胞瘤，缺乏神经外胚层分化的形态学，免疫组织化学和电子显微镜证据。它代表被称为尤因氏肉瘤/周围神经外胚层肿瘤的光谱的两端之一。它主要影响20岁以下的男性，可以发生在软组织或骨骼中。最常见的临床症状是疼痛和肿块。

一系列恶性肿瘤主要影响20岁以下的男性，其形态特征为小圆形细胞的出现。 尤文氏肉瘤和外周原始神经外胚层肿瘤代表了光谱的末端，而尤文氏肉瘤缺乏神经分化的证据和表征外周原始神经外胚层肿瘤的标记。 尤文氏肉瘤和外周原始神经外胚层肿瘤可能同时存在细胞遗传学异常，原癌基因表达，细胞培养和免疫组化异常。 这些肿瘤可能发生在软组织或骨骼中。 疼痛和肿块是最常见的临床症状。 - 2004年

A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms. -- 2004

A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.

A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.

A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. (From Dorland, 27th ed; Stedman, 25th ed)

总是出现在髓质组织中的骨骼恶性肿瘤，在圆柱形骨骼中更常发生。有明显的坏死灶，伴有不规则的小而规则的圆形或卵圆形细胞的团块，细胞质很少。肿瘤通常发生在20岁以前，男性发生率约为女性的两倍。 （来自Dorland，第27版; Stedman，第25版）

一系列恶性肿瘤主要影响20岁以下的男性，其形态特征是小圆形细胞的存在。尤文肉瘤和外周原始神经外胚层肿瘤代表了光谱的末端，因为尤因肉瘤缺乏神经分化的证据和表征外周原始神经外胚层肿瘤的标记。尤文肉瘤和外周原始神经外胚层肿瘤可能有共同的遗传学异常，原癌基因的表达、细胞培养、免疫组化异常。这些肿瘤可能发生在软组织或骨骼中。疼痛和肿块是最常见的临床症状。

GeneRIF:15919668

GeneRIF:12700668

GeneRIF:15581626

GeneRIF:11992404

GeneRIF:12557222

NCIt:C27291

SNOMEDCT:76909002

GeneRIF:12054564

GeneRIF:12172985

GeneRIF:15310753

GeneRIF:12527902

GeneRIF:11956622

DOID:3369

GeneRIF:14977835

GeneRIF:14528100

MSH:D012512

GeneRIF:15748890

GeneRIF:15077162

GeneRIF:15273724

GeneRIF:15282325

NCIt:C4817

GeneRIF:11313995

GeneRIF:12447693

GeneRIF:15328192

GeneRIF:15044653

尤文氏肉瘤

Ewings sarcoma

efo:EFO_0000174

Ewings sarcoma

URI: http://www.ebi.ac.uk/cellline#Ewing_sarcoma

http://purl.obolibrary.org/obo/clo.owl

Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Ewing's sarcoma (morphologic abnormality)

Ewing Tumor

尤文氏肿瘤(Ewing Tumor)

尤文氏肿瘤(Ewing's tumour)

尤文氏家族的肿瘤(Tumors of the Ewing's Family)

尤文氏家族肿瘤(Ewing's Family of Tumours)

尤文氏肉瘤/外周原始神经外胚层肿瘤

尤文氏肿瘤(Ewings Tumor)

Ewing Family of Tumors

尤文氏肉瘤/外周原始神经外胚层肿瘤（Ewing's Sarcoma / Peripheral Primitive Neuroectodermal Tumor）

尤文氏肉瘤（形态异常）

尤文氏肉瘤(Ewing sarcoma)

Ewing's Family of Tumors

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

尤文氏家族肿瘤(Ewing's Family of Tumors)

Tumors of the Ewing's Family

尤文氏家族的肿瘤(Ewing Family of Tumors)

Ewing's Family of Tumours

Ewing's tumour

ES

Ewing's sarcoma

Ewings Tumor

尤文氏肉瘤(Ewing's sarcoma)

Ewing sarcoma

James Malone

Tomasz Adamusiak

http://www.ebi.ac.uk/efo/EFO_0000637

http://purl.obolibrary.org/obo/DOID_171