loading...| Preferred Name |
GAIT complex |
| Synonyms |
gamma interferon-activated inhibitor of translation complex IFN-gamma-activated inhibitor of translation complex |
| Definitions |
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. |
| ID |
http://purl.obolibrary.org/obo/GO_0097452 |
| created_by |
paola |
| creation_date |
2012-12-19T09:32:25Z |
| definition |
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. |
| has_exact_synonym |
gamma interferon-activated inhibitor of translation complex IFN-gamma-activated inhibitor of translation complex |
| has_obo_namespace |
cellular_component |
| id |
GO:0097452 |
| label |
GAIT complex |
| notation |
GO:0097452 |
| prefLabel |
GAIT complex |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/GO_0097452 | Protein Ontology | LOOM | |
| http://purl.obolibrary.org/obo/GO_0097452 | Protein Ontology | SAME_URI |