Human Phenotype Ontology

Last uploaded: February 24, 2022
Preferred Name

Abnormal mast cell morphology

Synonyms

Abnormality of mastocytes

Abnormality of mast cells

Definitions

Mast cells (or mastocytes) can be found in several types of tissues and contain many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens. Mast cells possess a non-lobed nucleus and can work with basophils in the immune defense against worms. Their cell membrane is covered with Fc recepros that may be attached to class E antibodies. Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.

ID

http://purl.obolibrary.org/obo/HP_0100494

comment

Mast cells (or mastocytes) can be found in several types of tissues and contain many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens. Mast cells possess a non-lobed nucleus and can work with basophils in the immune defense against worms. Their cell membrane is covered with Fc recepros that may be attached to class E antibodies.

created_by

doelkens

creation_date

2010-12-17T04:02:08Z

database_cross_reference

UMLS:C1301149

SNOMEDCT_US:397017008

definition

Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.

has_exact_synonym

Abnormality of mastocytes

Abnormality of mast cells

has_obo_namespace

human_phenotype

id

HP:0100494

label

Abnormal mast cell morphology

notation

HP:0100494

prefLabel

Abnormal mast cell morphology

treeView

http://purl.obolibrary.org/obo/HP_0001911

subClassOf

http://purl.obolibrary.org/obo/HP_0001911

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