loading...| Preferred Name |
Puberty, Precocious |
| Synonyms |
Puberties, Familial Precocious |
| Definitions |
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. |
| ID |
http://purl.bioontology.org/ontology/MESH/D011629 |
| altLabel |
Puberties, Familial Precocious Familial Precocious Puberties Central Precocious Puberties Precocities, Sexual Pubertas Praecox Precocities, Idiopathic Sexual Sexual Precocity, Idiopathic Precocious Puberty, Familial Precocity, Sexual Puberties, Male-Limited Precocious Male-Limited Precocious Puberties Precocious Puberty, Male-Limited Central Precocious Puberty Sexual Precocities, Idiopathic Puberties, Precocious Precocious Puberty Sexual Precocities Precocious Puberties, Central Precocious Puberty, Central Precocity, Idiopathic Sexual Puberty, Familial Precocious Precocious Puberties Idiopathic Sexual Precocity Precocious Puberties, Male-Limited Idiopathic Sexual Precocities Puberty, Male-Limited Precocious Male-Limited Precocious Puberty Precocious Puberties, Familial Familial Precocious Puberty Praecox, Pubertas Puberties, Central Precocious Precocious Puberty, Male Limited Sexual Precocity Puberty, Central Precocious Testotoxicosis |
| AN |
human only |
| AQL |
BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VI |
| cui |
C0034013 C1504412 C0342543 C0271527 |
| DC |
1 |
| definition |
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. Familial precocious puberty in boys usually presents by age 4 with rapid VIRILIZATION and is also characterized by gonadotropin-independent testosterone secretion, low secretion of LUTEINIZING HORMONE, and advanced SPERMATOGENESIS in the testis. Mutations in the LHCGR gene have been identified. OMIM: 176410 An autosomal dominant hereditary disorder that is characterized by gonadotropin-dependent precocious puberty due to early activation of the hypothalamic-pituitary-gonadal axis. A mutation in the KISS1R gene has been identified. OMIM: 176400 |
| DX |
19660101 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000401 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000523 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000209 |
| Inverse of RO | |
| Inverse of SIB |
http://purl.bioontology.org/ontology/MESH/D013733 http://purl.bioontology.org/ontology/MESH/D010049 http://purl.bioontology.org/ontology/MESH/D011628 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C564568 http://purl.bioontology.org/ontology/MESH/C567552 http://purl.bioontology.org/ontology/MESH/C536961 http://purl.bioontology.org/ontology/MESH/C536874 |
| MDA |
19990101 |
| MMR |
20180228 |
| MN |
C19.391.693 |
| notation |
D011629 |
| prefLabel |
Puberty, Precocious |
| TERMUI |
T000935873 T000935870 T801502 T741004 T000935871 T609186 T801503 T000935872 T034340 T741007 |
| TH |
NLM (2006) OMIM (2014) NLM (1966) ORD (2010) OMIM (2013) GHR (2014) |
| tui |
T047 |
| subClassOf |