loading...| Preferred Name |
Primary Ovarian Insufficiency |
| Synonyms |
Ovarian Failure, Premature |
| Definitions |
A form of ovarian failure, caused by resistance to GONADOTROPINS stimulation. It may be caused by defects in the receptors for FOLLICLE STIMULATING HORMONE or LUTEINIZING HORMONE. It may be due to factors interfering with the actions of gonadotropins, such as antibodies blocking the ligand-receptor interaction. |
| ID |
http://purl.bioontology.org/ontology/MESH/D016649 |
| altLabel |
Ovarian Failure, Premature Fragile X Associated Primary Ovarian Insufficiency FMR1-Related Primary Ovarian Insufficiency Fragile X Premature Ovarian Failure Premature Ovarian Failure, X-Linked Primary Ovarian Insufficiency, Fragile X Associated X Linked Hypergonadotropic Ovarian Failure Premature Ovarian Failure 1 Primary Ovarian Insufficiency, Fragile X-Associated Gonadotropin Resistant Ovary Syndrome FMR1 Related Primary Ovarian Insufficiency Hypergonadotropic Ovarian Failure, X Linked Resistant Ovary Syndrome Premature Ovarian Failure, X Linked Hypergonadotropic Ovarian Failure, X-Linked X-Linked Hypergonadotropic Ovarian Failure Fragile X-Associated Primary Ovarian Insufficiency Ovarian Insufficiency, Primary Premature Ovarian Failure Gonadotropin-Resistant Ovary Syndrome |
| AQL |
BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI |
| cui |
C4552079 C0086367 C0085215 C3494522 |
| DC |
1 |
| definition |
A form of ovarian failure, caused by resistance to GONADOTROPINS stimulation. It may be caused by defects in the receptors for FOLLICLE STIMULATING HORMONE or LUTEINIZING HORMONE. It may be due to factors interfering with the actions of gonadotropins, such as antibodies blocking the ligand-receptor interaction. Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene. |
| DX |
19920101 |
| FX |
D008594 |
| HN |
2011(1992) |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000401 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000523 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000662 http://purl.bioontology.org/ontology/MESH/Q000151 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000209 |
| Inverse of RO | |
| Inverse of SIB |
http://purl.bioontology.org/ontology/MESH/D010051 http://purl.bioontology.org/ontology/MESH/D008594 http://purl.bioontology.org/ontology/MESH/D016471 http://purl.bioontology.org/ontology/MESH/D000858 |
| Machine permutation |
2011; see Ovarian Failure, Premature 1992-2010 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C563816 http://purl.bioontology.org/ontology/MESH/C566921 http://purl.bioontology.org/ontology/MESH/C567351 http://purl.bioontology.org/ontology/MESH/C567838 http://purl.bioontology.org/ontology/MESH/C535272 http://purl.bioontology.org/ontology/MESH/C564498 |
| MDA |
19910530 |
| MMR |
20180309 |
| MN |
C13.351.500.056.630.750 C19.391.630.750 |
| notation |
D016649 |
| prefLabel |
Primary Ovarian Insufficiency |
| TERMUI |
T811983 T811981 T049855 T767285 T810731 T841444 T810730 T811984 T049856 T608691 T845661 T841447 T049854 |
| TH |
NLM (2006) NLM (2011) NLM (1992) NLM (2014) OMIM (2013) GHR (2014) |
| tui |
T047 |
| subClassOf |