National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
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Preferred Name

Arylsulfatase A
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103932
code

C103932
DEFINITION

Arylsulfatase A (507 aa, ~54 kDa) is encoded by the human ARSA gene. This protein is involved in the hydrolysis of cerebroside sulfate.
DesignNote

Mutation of the SUMF1 gene results in misprocessing of arylsulfatase A and all other sulfatases leading to multiple sulfatase deficiency. (UniProt)

The conversion of a cysteine residue in eukaryotes to 3-oxoalanine (also known as C-formylglycine, FGly), is critical for catalytic activity. (UniProt)
FULL_SYN

ASA

Cerebroside-Sulfatase

EC 3.1.6.8

ARSA
label

Arylsulfatase A
OMIM_Number

607574
Preferred_Name

Arylsulfatase A
prefixIRI

C103932
prefLabel

Arylsulfatase A
Semantic_Type

Enzyme

Amino Acid, Peptide, or Protein
Swiss_Prot

P15289
UMLS_CUI

C0007804
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16561
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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/PR_000004321 Protein Ontology LOOM
http://purl.bioontology.org/ontology/OMIM/607574 Online Mendelian Inheritance in Man LOOM