National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Antineoplastic Alkylating Agent
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1590
code	C1590
DEFINITION	An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.
FULL_SYN	Chemotherapy Alkylators Chemotherapy Alkylating Agents
label	Antineoplastic Alkylating Agent
Legacy_Concept_Name	Antineoplastic_Alkylating_Agent
Preferred_Name	Antineoplastic Alkylating Agent
prefixIRI	C1590
prefLabel	Antineoplastic Alkylating Agent
Semantic_Type	Chemical Viewed Functionally
UMLS_CUI	C0282532
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

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