loading...| Preferred Name |
Cadherin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16373 |
| ALT_DEFINITION |
family of cell surface glycoproteins, first identified in vertebrates, that mediate calcium dependent, homophilic cell adhesion and thereby control tissue morphogenesis. |
| code |
C16373 |
| DEFINITION |
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. |
| label |
Cadherin |
| Legacy_Concept_Name |
Cadherin |
| Preferred_Name |
Cadherin |
| prefixIRI |
C16373 |
| prefLabel |
Cadherin |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C0006631 |
| subClassOf |