National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Cathepsin
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16389
code	C16389
DEFINITION	Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.
FULL_SYN	Cathepsins
label	Cathepsin
Legacy_Concept_Name	Cathepsin
Preferred_Name	Cathepsin
prefixIRI	C16389
prefLabel	Cathepsin
Semantic_Type	Enzyme Amino Acid, Peptide, or Protein
UMLS_CUI	C0007428
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16965

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	There are currently no mappings for this class.