National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Jump to:
Spinner 000000 16px loading...
Preferred Name

DNA Damage
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16507
code

C16507
DEFINITION

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
label

DNA Damage
Legacy_Concept_Name

DNA_Damage
Preferred_Name

DNA Damage
prefixIRI

C16507
prefLabel

DNA Damage
Semantic_Type

Cell or Molecular Dysfunction
UMLS_CUI

C0012860
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19154
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D004249 Medical Subject Headings LOOM