National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

HMG-CoA Reductase Inhibitor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1655

ALT_DEFINITION

Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol. Statin drugs are being studied in the prevention and treatment of cancer.

Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.

CHEBI_ID

CHEBI:35664

code

C1655

DEFINITION

Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels.

FULL_SYN

hydroxymethylglutaryl-coenzyme A reductase inhibitor

Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors

Statin

label

HMG-CoA Reductase Inhibitor

Legacy_Concept_Name

HMG-CoA_Reductase_Inhibitor

Preferred_Name

HMG-CoA Reductase Inhibitor

prefixIRI

C1655

prefLabel

HMG-CoA Reductase Inhibitor

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0360714

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29703

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471

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