Histone H4

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16686

C16686

Histone H4 (103 aa, ~11 kDa) is encoded by the human HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 genes. This protein plays a role in nucleating the formation of high order chromatin structures as a part of nucleosomes.

Histone H4 is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. The nucleosome interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures.

Histone H4 is encoded for by a cluster of genes that are clustered in the vicinity of 6p21.33 and all have the same SwissProt identifier.

Histone 1, H4

HIST1H4

Histone H4

Histone-H4

602833

602830

Histone H4

C16686

Histone H4

Amino Acid, Peptide, or Protein

P62805

C0019648

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16687