loading...| Preferred Name |
Neprilysin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16836 |
| code |
C16836 |
| DEFINITION |
Neprilysin (750 aa, ~86 kDa) is encoded by the human MME gene. This protein is involved in the metabolism of biologically active peptides. |
| DesignNote |
Membrane Metalloendopeptidase is a zinc-binding type II transmembrane glycoprotein that preferentially cleaves Gly-Phe bonds of peptides at the N side of hydrophobic residues and inactivates several peptide hormones, including insulin, glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin, as well as casein, hemoglobin, and other proteins and polypeptides. An important cell surface marker of human acute lymphocytic leukemia, MME is present on pre-B leukemic cells, which represent 85% of cases of ALL. |
| FULL_SYN |
CALLA Neutral Endopeptidase Enkephalinase Common Acute Lymphoblastic Leukemia Antigen Skin Fibroblast Elastase Membrane Metalloendopeptidase Common ALL Antigen MME EC 3.4.24.11 CD10 Antigen SFE Atriopeptidase Antigen CD10 NEP CD10 |
| label |
Neprilysin |
| Legacy_Concept_Name |
Membrane_Metalloendopeptidase |
| OMIM_Number |
120520 |
| Preferred_Name |
Neprilysin |
| prefixIRI |
C16836 |
| prefLabel |
Neprilysin |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P08473 |
| UMLS_CUI |
C0025250 |
| subClassOf |