National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Protein Tyrosine Kinase

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17020

code

C17020

DEFINITION

Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (Dictionary of Cell and Molecular Biology Online)

DesignNote

Formerly 2.7.1.112

FULL_SYN

EC 2.7.10

Tyrosine-Specific Protein Kinase

Tyrosine Protein Kinase

Protein-Tyrosine Kinase

PTK

Tyrosine Kinase

label

Protein Tyrosine Kinase

Legacy_Concept_Name

Protein_Tyrosine_Kinase

Preferred_Name

Protein Tyrosine Kinase

prefixIRI

C17020

prefLabel

Protein Tyrosine Kinase

Semantic_Type

Enzyme

Amino Acid, Peptide, or Protein

UMLS_CUI

C0033681

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17018

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