National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Beta Adrenergic Receptor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17062

code

C17062

DEFINITION

Expressed by Beta Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)

FULL_SYN

ADRB

label

Beta Adrenergic Receptor

Legacy_Concept_Name

Beta_Adrenergic_Receptor

Preferred_Name

Beta Adrenergic Receptor

prefixIRI

C17062

prefLabel

Beta Adrenergic Receptor

Semantic_Type

Amino Acid, Peptide, or Protein

Receptor

UMLS_CUI

C0034785

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18239

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/PR_000001121 Protein Ontology LOOM
http://purl.obolibrary.org/obo/FMA_67258 Foundational Model of Anatomy LOOM