loading...| Preferred Name |
Androgen Receptor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17063 |
| code |
C17063 |
| DEFINITION |
Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription. |
| DesignNote |
AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. |
| FULL_SYN |
DHTR Nuclear Receptor Subfamily 3 Group C Member 4 NR3C4 AR Dihydrotestosterone Receptor |
| label |
Androgen Receptor |
| Legacy_Concept_Name |
Androgen_Receptor |
| OMIM_Number |
313700 |
| Preferred_Name |
Androgen Receptor |
| prefixIRI |
C17063 |
| prefLabel |
Androgen Receptor |
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
| Swiss_Prot |
P10275 |
| UMLS_CUI |
C0034786 |
| subClassOf |