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loading...| Preferred Name |
Insulin Receptor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17072 |
| code |
C17072 |
| DEFINITION |
Insulin receptor (1382 aa, ~156 kDa) is encoded by the human INSR gene. This protein plays a role in both signal transduction and glucose homeostasis. |
| DesignNote |
Insulin receptor is cleaved to generate and alpha chain and a beta chain. The mature receptor is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. (UniProt) |
| FULL_SYN |
INSR CD220 IR Antigen CD220 EC 2.7.10.1 CD220 Antigen |
| label |
Insulin Receptor |
| Legacy_Concept_Name |
Insulin_Receptor |
| OMIM_Number |
147670 |
| Preferred_Name |
Insulin Receptor |
| prefixIRI |
C17072 |
| prefLabel |
Insulin Receptor |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein Receptor |
| Swiss_Prot |
P06213 |
| UMLS_CUI |
C0034818 |
| subClassOf |
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