loading...| Preferred Name |
Interleukin-2 Receptor Subunit Alpha |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17073 |
| code |
C17073 |
| DEFINITION |
Interleukin-2 receptor subunit alpha (272 aa, ~31 kDa) is encoded by the human IL2RA gene. This protein plays a role in interleukin-2-dependent signaling. |
| DesignNote |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. (LocusLink) |
| FULL_SYN |
T-Cell Growth Factor Receptor Interleukin-2 Receptor Alpha Chain IL-2-RA Low Affinity Interleukin 2 Receptor Interleukin 2 Receptor p55 Interleukin 2 Receptor, Alpha IL-2 Receptor TAC Antigen IL-2R Subunit Alpha IL2RA IL-2 Receptor Subunit Alpha IL2R IL2 Receptor IL2-RA IL-2R CD25 |
| label |
Interleukin-2 Receptor Subunit Alpha |
| Legacy_Concept_Name |
Interleukin-2_Receptor_Alpha |
| OMIM_Number |
147730 |
| Preferred_Name |
Interleukin-2 Receptor Subunit Alpha |
| prefixIRI |
C17073 |
| prefLabel |
Interleukin-2 Receptor Subunit Alpha |
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
| Swiss_Prot |
P01589 |
| UMLS_CUI |
C1101536 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/PR_000001380 | Cell Ontology | LOOM | |
| http://purl.obolibrary.org/obo/PR_000001380 | Protein Ontology | LOOM |