National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Aromatase Inhibitor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1740

ALT_DEFINITION

A drug that prevents the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy for postmenopausal women who have hormone-dependent breast cancer.

CHEBI_ID

CHEBI:50790

code

C1740

DEFINITION

Any substance that inhibits aromatase, an enzyme responsible for the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Inhibition of aromatase results in the suppression of estrogen-regulated processes.

FULL_SYN

Estrogen Synthase Inhibitor

Estrogen Synthetase Inhibitor

Androstenedione Aromatase Inhibitor

label

Aromatase Inhibitor

Legacy_Concept_Name

Aromatase_Inhibitor

Preferred_Name

Aromatase Inhibitor

prefixIRI

C1740

prefLabel

Aromatase Inhibitor

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0593802

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471

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