loading...| Preferred Name |
Proto-Oncogene c-Fos |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17438 |
| code |
C17438 |
| DEFINITION |
Proto-oncogene c-Fos (380 aa, ~41 kDa) is encoded by the human FOS gene. This protein is involved in transcriptional regulation, DNA binding and signal transduction. |
| DesignNote |
FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members. Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes. (from OMIM 164810) |
| FULL_SYN |
FOS Protein G0/G1 Switch Regulatory Protein 7 FBJ Murine Osteosarcoma Viral Oncogene Homolog c-fos Protein Cellular Oncogene Fos FOS |
| label |
Proto-Oncogene c-Fos |
| Legacy_Concept_Name |
FOS_Protein |
| OMIM_Number |
164810 |
| Preferred_Name |
Proto-Oncogene c-Fos |
| prefixIRI |
C17438 |
| prefLabel |
Proto-Oncogene c-Fos |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P01100 |
| UMLS_CUI |
C0596588 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/PR_000007597 | Phenotypic Quality Ontology | LOOM | |
| http://purl.obolibrary.org/obo/PR_000007597 | Cell Ontology | LOOM | |
| http://purl.obolibrary.org/obo/PR_000007597 | Protein Ontology | LOOM |