Insulin-Like Growth Factor-Binding Protein 1

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17505

C17505

Insulin-like growth factor-binding protein 1 (259 aa, ~28 kDa) is encoded by the human IGFBP1 gene. This protein is involved in cell migration and both insulin-like growth factor binding and signaling.

Encoded by human IGFBP1 Gene and expressed in liver, endometrium, and decidua, low molecular weight secreted 259-aa 29-kD Insulin-Like Growth Factor-Binding Protein 1 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP1 binds equally to plasma IGF I and IGF II with high affinity. The protein has 15 N- and C-terminal cysteines and a C-terminal RGD sequence that may promote potentiation of IGF I biologic actions. IGFBP1 is probably phosphorylated by casein kinase II, which alters IGF affinity. IGF-binding proteins prolong the half-life of IGFs and alter IGF interactions with cell surface receptors.

IGFBP1 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP1 is synthesized in liver, secretory endometrium and decidua. It binds IGF-I and IGF-II with equal affinity and phosphorylation alters its affinity for IGFs. IGFBP1 potentiates IGF-I action and its C-terminal RGD sequence may account for its ability to attach to cells and potentiate IGF-I action. IGFBP1 may act as a paracrine regulator of cell growth.

IGFBP-1

Binding Protein-28

AFBP

Growth Hormone Independent-Binding Protein

Binding Protein-26

PP12

IGF Binding Protein 1

Amniotic Fluid Binding Protein

Placental Protein 12

Insulin-Like Growth Factor Binding Protein 1

IBP-1

IGF-Binding Protein 1

IGFBP1

Alpha-Pregnancy-Associated Endometrial Globulin

Binding Protein-25

Insulin-Like Growth Factor-Binding Protein 1

Insulin-Like_Growth_Factor-Binding_Protein-1

146730

Insulin-Like Growth Factor-Binding Protein 1

C17505

Insulin-Like Growth Factor-Binding Protein 1

Biologically Active Substance

Amino Acid, Peptide, or Protein

P08833

C0123256

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17332