loading...| Preferred Name |
L-Selectin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17512 |
| code |
C17512 |
| DEFINITION |
L-selectin (372 aa, ~42 kDa) is encoded by the human SELL gene. This protein plays a role in leukocyte adhesion and rolling. |
| DesignNote |
L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units. L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation. A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain. PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules. |
| FULL_SYN |
gp90-MEL LAM-1 Leukocyte Adhesion Molecule 1 LECAM1 TQ1 CD62L Antigen CD62L Pln Homing Receptor Selectin L Lymph Node Homing Receptor SELL Leukocyte-Endothelial Cell Adhesion Molecule 1 Lymphocyte Adhesion Molecule 1 CD62 Antigen-Like Family Member L CD62 Antigen Ligand Leukocyte Surface Antigen Leu-8 |
| label |
L-Selectin |
| Legacy_Concept_Name |
Selectin-L |
| OMIM_Number |
153240 |
| Preferred_Name |
L-Selectin |
| prefixIRI |
C17512 |
| prefLabel |
L-Selectin |
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
| Swiss_Prot |
P14151 |
| UMLS_CUI |
C0125090 |
| subClassOf |