Junction Plakoglobin

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17524

C17524

Junction plakoglobin (744 aa, ~82 kDa) is encoded by the human JUP gene. This protein is involved in adherens junction assembly.

Plakoglobin (gamma-Catenin) is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions. It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions. The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR. APC binds to and regulates beta- and gamma-Catenin. Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway. Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function. Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes.

Gamma-Catenin

Desmoplakin III

Desmoplakin-3

DP III

Catenin Gamma

Plakoglobin

JUP

Gamma Catenin

Junction Plakoglobin

Junction_Plakoglobin

173325

Junction Plakoglobin

C17524

Junction Plakoglobin

Amino Acid, Peptide, or Protein

P14923

C0137209

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16393