Retinoic Acid Receptor

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17532

C17532

Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.

A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI)

RAR

Retinoid Receptor

Nuclear Receptor Subfamily 1 Group B

Retinoic Acid Receptor

Retinoic_Acid_Receptor

Retinoic Acid Receptor

C17532

Retinoic Acid Receptor

Amino Acid, Peptide, or Protein

Receptor

C0140278

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17671