National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Apoptosis

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17557

ALT_DEFINITION

A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.

code

C17557

DEFINITION

A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell.

DesignNote

Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.

FULL_SYN

Programmed Cell Death

Apoptotic Process

PCD

label

Apoptosis

Legacy_Concept_Name

Apoptosis

Preferred_Name

Apoptosis

prefixIRI

C17557

prefLabel

Apoptosis

Semantic_Type

Phenomenon or Process

UMLS_CUI

C0162638

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41515

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http://purl.bioontology.org/ontology/MESH/D017209 Medical Subject Headings LOOM