National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Nuclear Receptor
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17671
code	C17671
DEFINITION	Proteins that regulate transcription via interaction with chromatin and basal transcription machinery at the promoter regions of genes. Nuclear receptors are ligand-dependent transcription factors including steroids, retinoids, vitamin D, unliganded thyroid hormone, and orphan receptors (unknown ligands). Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulate positive or negative receptor activity.
FULL_SYN	Receptor, Nuclear
label	Nuclear Receptor
Legacy_Concept_Name	Nuclear_Receptor
Preferred_Name	Nuclear Receptor
prefixIRI	C17671
prefLabel	Nuclear Receptor
Semantic_Type	Amino Acid, Peptide, or Protein Receptor
UMLS_CUI	C0206588
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17207 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18106

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Delete	Mapping To	Ontology	Source
	There are currently no mappings for this class.