loading...| Preferred Name |
Furin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17902 |
| code |
C17902 |
| DEFINITION |
Furin (794 aa, ~87 kDa) is encoded by the human FURIN gene. This protein is involved in endopeptidase activity and the secretory pathway. |
| DesignNote |
Furin cleaves protein substrates at RX(K/R)R consensus motifs. Furin is synthesized as a proenzyme that contains an autoinhibitory peptide sequence. This inhibitory peptide domain must be proteolytically processed twice to generate the active furin molecule. The first cleavage occurs autocatalytically in the endoplasmic reticulum but the inhibitory peptide remains bound until the second cleavage occurs in the trans-Golgi network. (UniProt) |
| FULL_SYN |
EC 3.4.21.75 Paired Basic Amino Acid Cleaving Enzyme PACE Paired Basic Amino Acid Residue-Cleaving Enzyme Furin Preproprotein Dibasic-Processing Enzyme PACE Protein |
| label |
Furin |
| Legacy_Concept_Name |
Furin_Preproprotein |
| OMIM_Number |
136950 |
| Preferred_Name |
Furin |
| prefixIRI |
C17902 |
| prefLabel |
Furin |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P09958 |
| UMLS_CUI |
C0287990 |
| subClassOf |