loading...| Preferred Name |
Transcription Factor PU.1 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18036 |
| code |
C18036 |
| DEFINITION |
Transcription factor PU.1 (270 aa, ~31 kDa) is encoded by the human SPI1 gene. This protein plays a role in transcriptional regulation in hematopoietic cells. |
| DesignNote |
Transcription factor PU.1 binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3'). (UniProt) Normally expressed in all hematopoietic lineages, except T-cells, the ETS-domain PU.1 Transcription Factor is essential for development of myeloid (osteoclast progenitors) and B-lymphoid cells. Graded PU.1 expression appears to specify distinct cell fates in the hematopoietic system; a low concentration induces the B-cell fate, while a high concentration promotes macrophage differentiation. PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells. PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3. (OMIM) |
| FULL_SYN |
PU.1 Transcription Factor SPI1 Protein SPI1 SPI1 Gene Product 31 kDa-Transforming Protein |
| label |
Transcription Factor PU.1 |
| Legacy_Concept_Name |
PU-1_Transcription_Factor |
| OMIM_Number |
165170 |
| Preferred_Name |
Transcription Factor PU.1 |
| prefixIRI |
C18036 |
| prefLabel |
Transcription Factor PU.1 |
| Semantic_Type |
Biologically Active Substance Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P17947 |
| UMLS_CUI |
C0246120 |
| subClassOf |