loading...| Preferred Name |
Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18181 |
| ALT_DEFINITION |
A protein that helps control many cell functions, including cell division and cell death. Mutations (changes) in the gene that makes PTEN are found in many types of cancer and other diseases. It is a type of tumor suppressor protein. |
| code |
C18181 |
| DEFINITION |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN gene. This protein plays a role in signaling and as both a dual-specificity phosphoprotein phosphatase and a lipid phosphatase. |
| DesignNote |
PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin). PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis. PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation. |
| FULL_SYN |
PTEN Tyrosine Phosphatase Mutated in Multiple Advanced Cancers 1 EC 3.1.3.67 PTEN Phosphatase and Tensin Homolog EC 3.1.3.16 EC 3.1.3.48 |
| label |
Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN |
| Legacy_Concept_Name |
PTEN_Tyrosine_Phosphatase |
| OMIM_Number |
601728 |
| Preferred_Name |
Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN |
| prefixIRI |
C18181 |
| prefLabel |
Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P60484 |
| UMLS_CUI |
C1430988 |
| subClassOf |