loading...| Preferred Name |
Runt-Related Transcription Factor 1 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18319 |
| code |
C18319 |
| DEFINITION |
Runt-related transcription factor 1 (453 aa, ~49 kDa) is encoded by the human RUNX1 gene. This protein is involved in the promotion of gene transcription and hematopoiesis. |
| DesignNote |
Part of the heterodimeric transcription factor Core-Binding Factor. The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA. |
| FULL_SYN |
Acute Myeloid Leukemia 1 Protein AML1 Protein Oncogene AML-1 PEA2-Alpha B Core-Binding Factor Alpha CBFA2 Core-Binding Factor Alpha B Subunit SL3-3 Enhancer Factor 1 Alpha B Subunit Core-Binding Factor, Runt Domain, Alpha Subunit 2 AML-1 Protein RUNX1 CBF-Alpha SL3/AKV Core-Binding Factor Alpha B Subunit Polyomavirus Enhancer Binding Protein 2 Alpha B Subunit CBF-Alpha-2 AML1 Core-Binding Factor Subunit Alpha-2 AML-1 CBF-Alpha B Acute Myeloid Leukemia-1 Protein PEBP2-Alpha B Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit |
| label |
Runt-Related Transcription Factor 1 |
| Legacy_Concept_Name |
Core-Binding_Factor_Alpha |
| OMIM_Number |
151385 |
| Preferred_Name |
Runt-Related Transcription Factor 1 |
| prefixIRI |
C18319 |
| prefLabel |
Runt-Related Transcription Factor 1 |
| Semantic_Type |
Biologically Active Substance Amino Acid, Peptide, or Protein |
| Swiss_Prot |
Q01196 |
| UMLS_CUI |
C0215508 |
| subClassOf |