Nuclear Factor NF-kappa-B p100 Subunit

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18550

C18550

Nuclear factor NF-kappa-B p100 subunit (900 aa, ~97 kDa) is encoded by the human NFKB2 gene. This protein plays a role in both transcriptional regulation and signal transduction.

NFKB2 belongs to the Rel/Dorsal family, contains seven ANK repeats, and binds to REL (p65) proteins to form NFKB, which is trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (from SWISS-PROT Q00653, OMIM 164012, and NCI)

100Kd and 49Kd products by alternate splicing

Nuclear factor NF-kappa-B p100 subunit is proteolytically processed to form nuclear factor NF-kappa-B p52 subunit.

NF-kB Subunit 2

LYT10 Protein

DNA-Binding Factor KBF2

Oncogene Lyt-10

NF-Kappa B p49/p100

Transcription Factor NFKB2

Nuclear Factor Kappa-B Subunit 2

Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 2

Nuclear Factor of Kappa Light Chain Gene Enhancer in B-Cells 2

NFKB2 Protein

Lymphocyte Translocation Chromosome 10 Protein

NFKB p49/p100 Subunit

Nuclear Factor Kappa B Subunit 2

NFKB2

NF-kappa-B2

Lyt10

NF-kappaB(p50)

H2TF1

Nuclear Factor NF-kappa-B p100 Subunit

NF-Kappa_B_p49-p100_Protein

164012

Nuclear Factor NF-kappa-B p100 Subunit

C18550

Nuclear Factor NF-kappa-B p100 Subunit

Biologically Active Substance

Amino Acid, Peptide, or Protein

Q00653

C0212691

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17207