loading...| Preferred Name |
Interleukin-17A |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20519 |
| code |
C20519 |
| DEFINITION |
Interleukin-17A (155 aa, ~18 kDa) is encoded by the human IL17A gene. This protein is involved in the positive regulation of cytokine production. |
| DesignNote |
Interleukin-17A enhances expression of IL6, IL8, and ICAM-1 in fibroblasts, regulates the activities of NF-kappaB and mitogen-activated protein kinases, stimulates the expressionn cyclooxygenase-2 (PTGS2/COX-2), enhances the production of nitric oxide (NO) and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation. |
| FULL_SYN |
IL-17A IL-17 IL17A IL17 CTLA8 Interleukin-17 Interleukin 17 Interleukin 17 Precursor Cytotoxic T-Lymphocyte-Associated Antigen 8 CTLA-8 Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 IL17 Protein |
| label |
Interleukin-17A |
| Legacy_Concept_Name |
Interleukin-17 |
| OMIM_Number |
603149 |
| Preferred_Name |
Interleukin-17A |
| prefixIRI |
C20519 |
| prefLabel |
Interleukin-17A |
| Semantic_Type |
Immunologic Factor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
Q16552 |
| UMLS_CUI |
C1705947 |
| subClassOf |