National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Mediator Complex Component Gene
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20658
code	C20658
DEFINITION	Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Mediator Complex Component Genes encode the mediator complex, one type of intermediary and which consists of approximately 20 polypeptides. It is physically associated with RNA polymerase II and is essential for transcriptional activation. (from OMIM 602984)
label	Mediator Complex Component Gene
Legacy_Concept_Name	Mediator_Complex_Component_Gene
Preferred_Name	Mediator Complex Component Gene
prefixIRI	C20658
prefLabel	Mediator Complex Component Gene
Semantic_Type	Gene or Genome
UMLS_CUI	C1334684
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20673

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