National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Transcription Coactivator Gene

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20673

code

C20673

DEFINITION

RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. The combined action of general and gene-specific regulators encoded by Transcription Coactivator Genes enhances gene expression. (NCI)

Gene_Encodes_Product

Transcription Coactivator

label

Transcription Coactivator Gene

Legacy_Concept_Name

Transcription_Coactivator_Gene

Preferred_Name

Transcription Coactivator Gene

prefixIRI

C20673

prefLabel

Transcription Coactivator Gene

Semantic_Type

Gene or Genome

UMLS_CUI

C1336777

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20710

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