National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Transcription Coregulator Gene

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20710

code

C20710

DEFINITION

RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)

FULL_SYN

Transcription Coactivator/Corepressor Gene

Transcriptional Coregulator Gene

label

Transcription Coregulator Gene

Legacy_Concept_Name

Transcription_Coregulator_Gene

Preferred_Name

Transcription Coregulator Gene

prefixIRI

C20710

prefLabel

Transcription Coregulator Gene

Semantic_Type

Gene or Genome

UMLS_CUI

C1336778

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54362

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