National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Class II AP Endonuclease

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21422

code

C21422

DEFINITION

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. (From LocusLink 27301)

label

Class II AP Endonuclease

Legacy_Concept_Name

Class-II_AP-Endonuclease

Preferred_Name

Class II AP Endonuclease

prefixIRI

C21422

prefLabel

Class II AP Endonuclease

Semantic_Type

Enzyme

UMLS_CUI

C1333055

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16804

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16499

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