loading...| Preferred Name |
Gastrin-Releasing Peptide |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2272 |
| CAS_Registry |
80043-53-4 |
| code |
C2272 |
| DEFINITION |
Gastrin-releasing peptide (27 aa, ~3 kDa) is encoded by the human GRP gene. This protein is involved in hormone signaling in both the gastrointestinal and nervous systems. |
| DesignNote |
Gastrin-releasing peptide (GRP) is the equivalent in mammals of the amphibian bombesin. Infusion of either GRP or bombesin increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. It is widely distributed in the gastrointestinal tract and in the nervous system. In normal adult mammal GRP is strictly a neuropeptide and functions in a neurotransmitter-like fashion. In the fetus, a larger form of GRP acts as a hormone and exerts growth factor-like activity on many organs, aiding in development. Gastrin-releasing peptide is comprised of amino acids 24-50 of pre-progastrin-releasing peptide. |
| FULL_SYN |
GRP Gastrin Releasing Peptide Mammalian Bombesin |
| label |
Gastrin-Releasing Peptide |
| Legacy_Concept_Name |
Gastrin_Releasing_Peptide |
| OMIM_Number |
137260 |
| Preferred_Name |
Gastrin-Releasing Peptide |
| prefixIRI |
C2272 |
| prefLabel |
Gastrin-Releasing Peptide |
| Semantic_Type |
Hormone Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P07492 |
| UMLS_CUI |
C0061132 |
| subClassOf |