National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Angiotensin

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C248

code

C248

DEFINITION

Expressed in liver by human AGT Gene (Serpin Family), secreted 485-aa 53-kDa Angiotensinogen is cleaved by renin (in response to lowered blood pressure) to inactive decapeptide Angiotensin I, which is cleaved by ACE to generate active octapeptide vasopressor Angiotensin II (maintains blood pressure and regulates the volume and mineral balance of body fluids). Angiotensin II is cleaved to Angiotensin III heptapeptide, an aldosterone stimulant.

label

Angiotensin

Legacy_Concept_Name

Angiotensin

OMIM_Number

106150

Preferred_Name

Angiotensin

prefixIRI

C248

prefLabel

Angiotensin

Semantic_Type

Hormone

Amino Acid, Peptide, or Protein

Swiss_Prot

P01019

UMLS_CUI

C0003018

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1746

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http://purl.bioontology.org/ontology/LNC/LP40491-0 Logical Observation Identifier Names and Codes LOOM
http://purl.obolibrary.org/obo/CHEBI_48433 Chemical Entities of Biological Interest Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_48433 International Classification of Diseases Ontology LOOM
http://purl.bmicc.cn/ontology/ICD11CN/XM10L5 International Classification of Diseases, 11th Edition, China LOOM