National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Retinoic Acid Binding

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26052

code

C26052

DEFINITION

Retinoic Acid Binding consists of a biophysical interaction between retinoic acid (ligand) and a biological molecule, such as specific steroid receptor-like transcriptional regulator proteins containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal ligand-binding domain. The ligand-activated receptor complexes selectively bind as homodimers or heterodimers (with other steroid family receptors) to DNA response elements in target gene promoters, enhance transcriptional activity with coactivators, and mediate tissue growth and differentiation in embryogenesis, organogenesis, limb development, bone growth, and maintenance of normal epithelia.

label

Retinoic Acid Binding

Legacy_Concept_Name

Retinoic_Acid_Binding

Preferred_Name

Retinoic Acid Binding

prefixIRI

C26052

prefLabel

Retinoic Acid Binding

Semantic_Type

Molecular Function

UMLS_CUI

C1514916

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20139

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http://purl.obolibrary.org/obo/GO_0001972 Gene Ontology LOOM