CX3C Chemokine Receptor 1

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26209

C26209

CX3C chemokine receptor 1 (355 aa, ~40 kDa) is encoded by the human CX3CR1 gene. This protein plays a role in cell adhesion, chemotaxis, cell defense response and signal transduction.

Up-regulated by chronic inflammation and encoded by human CX3CR1 Gene (CCR Family, Rhodopsin Family), 355-amino acid 40.4-kD high-affinity Fractalkine Receptor is a seven transmembrane protein expressed in brain, peripheral blood leukocytes, and spleen as a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM)

Fractalkine Receptor CX3CR1

CX3CR1 Protein

G-Protein Coupled Receptor Family 1

V28

CX3CR1

G Protein-Coupled Receptor 13

G Protein-Coupled Receptor V28

CMK-BRL1

Fractalkine Receptor

Chemokine (C-X3-C Motif) Receptor 1

Chemokine, CX3C Motif, Receptor 1

CMK-BRL-1

G-Protein Coupled Receptor 13

Beta Chemokine Receptor-Like 1

CMKBLR1

Chemokine (C-C) Receptor-Like 1

C-X3-C CKR-1

CX3C Chemokine Receptor 1

Fractalkine_Receptor

601470

CX3C Chemokine Receptor 1

C26209

CX3C Chemokine Receptor 1

Amino Acid, Peptide, or Protein

Receptor

P49238

C1143767

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18018