National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Killer Cell Lectin-Like Receptor Subfamily B Member 1

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26477

code

C26477

DEFINITION

Killer cell lectin-like receptor subfamily B member 1 (225 aa, ~25 kDa) is encoded by the human KLRB1 gene. This protein plays a role in the modulation of natural killer cell cytotoxicity.

DesignNote

Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI)

FULL_SYN

Natural Killer Cell Surface Protein P1A

KLRB1

NKR-P1

CD161

Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Protein

NKR-P1A

NKRP1A Protein

CD161 Antigen

NKR

C-Type Lectin Domain Family 5 Member B

Killer Cell Lectin-Like Receptor Subfamily B, Member 1

hNKR-P1A

label

Killer Cell Lectin-Like Receptor Subfamily B Member 1

Legacy_Concept_Name

NKRP1A_Protein

OMIM_Number

602890

Preferred_Name

Killer Cell Lectin-Like Receptor Subfamily B Member 1

prefixIRI

C26477

prefLabel

Killer Cell Lectin-Like Receptor Subfamily B Member 1

Semantic_Type

Immunologic Factor

Amino Acid, Peptide, or Protein

Swiss_Prot

Q12918

UMLS_CUI

C0132638

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16725

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/OMIM/602890 Online Mendelian Inheritance in Man LOOM
http://purl.obolibrary.org/obo/PR_000025670 Cell Ontology LOOM
http://purl.obolibrary.org/obo/PR_000025670 Protein Ontology LOOM