National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Sjogren Syndrome

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26883

ALT_DEFINITION

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

Autoimmune epithelial inflammation often affecting the salivary and lacrimal glands (causing dry mouth and dry eyes) with potential extraglandular manifestations. In children, it most commonly presents with recurrent parotitis. It may occur alone (primary) or in association with another autoimmune disease (secondary).

An autoimmune disease that affects the tear glands and salivary glands, and may affect glands in the stomach, pancreas, and intestines. The disease causes dry eyes and mouth, and may cause dryness in the nose, throat, air passages, skin, and vagina. It may also cause inflammation in the joints, muscles, and skin; pneumonia; tingling in the fingers and toes; and fatigue. It often occurs with rheumatoid arthritis or other connective tissue diseases.

code

C26883

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54450

Contributing_Source

NICHD

FDA

DEFINITION

An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus.

FDA_Table

Patient Code (Appendix B)

FULL_SYN

Sjogren's Syndrome

Syndrome, Sjogren's

Sjögren Syndrome

Has_CDRH_Parent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2889

Has_NICHD_Parent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2889

label

Sjogren Syndrome

Legacy_Concept_Name

Sjogren_s_Syndrome

NICHD_Hierarchy_Term

Sjogren Syndrome

Preferred_Name

Sjogren Syndrome

prefixIRI

C26883

prefLabel

Sjogren Syndrome

Semantic_Type

Disease or Syndrome

UMLS_CUI

C1527336

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28193

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2889

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http://purl.bioontology.org/ontology/OMIM/270150 Online Mendelian Inheritance in Man LOOM
http://purl.bioontology.org/ontology/OMIM/MTHU027841 Online Mendelian Inheritance in Man LOOM