Preferred Name |
Sjogren Syndrome |
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26883 |
ALT_DEFINITION |
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. Autoimmune epithelial inflammation often affecting the salivary and lacrimal glands (causing dry mouth and dry eyes) with potential extraglandular manifestations. In children, it most commonly presents with recurrent parotitis. It may occur alone (primary) or in association with another autoimmune disease (secondary). An autoimmune disease that affects the tear glands and salivary glands, and may affect glands in the stomach, pancreas, and intestines. The disease causes dry eyes and mouth, and may cause dryness in the nose, throat, air passages, skin, and vagina. It may also cause inflammation in the joints, muscles, and skin; pneumonia; tingling in the fingers and toes; and fatigue. It often occurs with rheumatoid arthritis or other connective tissue diseases. |
code |
C26883 |
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468 |
Contributing_Source |
NICHD FDA |
DEFINITION |
An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus. |
FDA_Table |
Patient Code (Appendix B) |
FULL_SYN |
Sjogren's Syndrome Syndrome, Sjogren's Sjögren Syndrome |
Has_CDRH_Parent | |
Has_NICHD_Parent | |
label |
Sjogren Syndrome |
Legacy_Concept_Name |
Sjogren_s_Syndrome |
NICHD_Hierarchy_Term |
Sjogren Syndrome |
Preferred_Name |
Sjogren Syndrome |
prefixIRI |
C26883 |
prefLabel |
Sjogren Syndrome |
Semantic_Type |
Disease or Syndrome |
UMLS_CUI |
C1527336 |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.bioontology.org/ontology/OMIM/270150 | Online Mendelian Inheritance in Man | LOOM | |
http://purl.bioontology.org/ontology/OMIM/MTHU027841 | Online Mendelian Inheritance in Man | LOOM |