National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Nifedipine
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29290
CAS_Registry	21829-25-4
CHEBI_ID	CHEBI:7565
Chemical_Formula	C17H18N2O6
code	C29290
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
FDA_UNII_Code	I9ZF7L6G2L
FULL_SYN	Adalat Procardia
label	Nifedipine
Legacy_Concept_Name	Nifedipine
Preferred_Name	Nifedipine
prefixIRI	C29290
prefLabel	Nifedipine
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C0028066
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/LNC/LP17866-2	Logical Observation Identifier Names and Codes	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024723	Logical Observation Identifier Names and Codes	LOOM
http://purl.obolibrary.org/obo/CHEBI_7565	Chemical Entities of Biological Interest Ontology	LOOM
http://purl.bioontology.org/ontology/MESH/D009543	Medical Subject Headings	LOOM
http://purl.bmicc.cn/ontology/ICD11CN/XM3N90	International Classification of Diseases, 11th Edition, China	LOOM