National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Calcium Channel Blocker

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333

ALT_DEFINITION

A pharmaceutical agent that inhibits the movement of calcium across through calcium channels in the cell membrane, preventing or decreasing the amount of calcium able to enter the cell. These drugs are used for their chronotropic, antihypertensive and vasodilatory effects.

A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.

CHEBI_ID

CHEBI:38215

code

C333

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259

Contributing_Source

NICHD

DEFINITION

A pharmaceutical agent that inhibits the movement of calcium across through calcium channels in the cell membrane, preventing or decreasing the amount of calcium able to enter the cell. These drugs are used for their chronotropic, antihypertensive and vasodilatory effects.

FULL_SYN

CCB

Has_NICHD_Parent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Calcium Channel Blocker

Legacy_Concept_Name

Calcium_Channel_Blocker

NICHD_Hierarchy_Term

Calcium Channel Blocker

Preferred_Name

Calcium Channel Blocker

prefixIRI

C333

prefLabel

Calcium Channel Blocker

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0006684

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C270

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http://purl.obolibrary.org/obo/CHEBI_38215 Chemical Entities of Biological Interest Ontology LOOM