National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Cefotaxime
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354
CAS_Registry	63527-52-6
CHEBI_ID	CHEBI:204928
Chemical_Formula	C16H17N5O7S2
code	C354
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.
FDA_UNII_Code	N2GI8B1GK7
Has_Salt_Form	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2328
label	Cefotaxime
Legacy_Concept_Name	Cefotaxime
PDQ_Closed_Trial_Search_ID	39177
PDQ_Open_Trial_Search_ID	39177
Preferred_Name	Cefotaxime
prefixIRI	C354
prefLabel	Cefotaxime
Semantic_Type	Organic Chemical Antibiotic
UMLS_CUI	C0007554
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/LNC/MTHU002074	Logical Observation Identifier Names and Codes	LOOM
http://purl.bioontology.org/ontology/LNC/LP14831-9	Logical Observation Identifier Names and Codes	LOOM
http://purl.bmicc.cn/ontology/ICD11CN/XM7CZ4	International Classification of Diseases, 11th Edition, China	LOOM
http://purl.bioontology.org/ontology/MESH/D002439	Medical Subject Headings	LOOM
http://purl.obolibrary.org/obo/CHEBI_204928	Chemical Entities of Biological Interest Ontology	LOOM
http://purl.obolibrary.org/obo/CHEBI_204928	GenEpiO	LOOM
http://purl.obolibrary.org/obo/CHEBI_204928	Human Disease Ontology 123	LOOM