loading...| Preferred Name |
Gastrointestinal Stromal Tumor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3868 |
| ALT_DEFINITION |
A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant. |
| code |
C3868 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103117 |
| Contributing_Source |
CTEP CTRP |
| DEFINITION |
A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. |
| Display_Name |
Gastrointestinal Stromal Tumor |
| FULL_SYN |
GIST Gastrointestinal Stromal Neoplasm |
| ICD-O-3_Code |
8936/1 |
| label |
Gastrointestinal Stromal Tumor |
| Legacy_Concept_Name |
Gastrointestinal_Stromal_Tumor |
| Neoplastic_Status |
Undetermined |
| Preferred_Name |
Gastrointestinal Stromal Tumor |
| prefixIRI |
C3868 |
| prefLabel |
Gastrointestinal Stromal Tumor |
| Semantic_Type |
Neoplastic Process |
| UMLS_CUI |
C0238198 |
| subClassOf |