Cell Cycle Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38794

Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.

C38794

Cell Cycle

hsa04110

Cell Cycle Pathway

Cell_Cycle_Pathway

CL322969

Cell Cycle Pathway

C38794

Cell Cycle Pathway

Functional Concept

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39700