National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Glycolysis/Gluconeogenesis Pathway

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38818

ALT_DEFINITION

Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module, which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from non-carbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths.

code

C38818

FULL_SYN

Glycolysis / Gluconeogenesis

KEGG_ID

hsa00010

label

Glycolysis/Gluconeogenesis Pathway

Legacy_Concept_Name

Glycolysis_Gluconeogenesis_Pathway

Preferred_Name

Glycolysis/Gluconeogenesis Pathway

prefixIRI

C38818

prefLabel

Glycolysis/Gluconeogenesis Pathway

Semantic_Type

Functional Concept

UMLS_CUI

C1512230

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39726

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http://purl.obolibrary.org/obo/PW_0000025 Pathway Ontology LOOM