loading...| Preferred Name |
CCAAT/Enhancer Binding Protein Alpha |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45488 |
| code |
C45488 |
| DEFINITION |
CCAAT/enhancer binding protein alpha (358 aa, ~38 kD) is encoded by the human CEBPA gene. This nuclear protein is a DNA-binding bZIP transcription factor that, as a homodimer, recognizes common motifs in both the promoter (CCAAT sequence) and enhancer (core homology sequence) regions of genes. |
| DesignNote |
CEBPA protein binds to the leptin gene promoter and modulates expression of the leptin protein, which is important in body weight homeostasis. CEBPA protein interacts with CDK2 and CDK4, thereby inhibiting kinase activity which results in cell growth arrest. This protein also plays an important role in the differentiation of immature granulocytes. |
| FULL_SYN |
CEBP CEBPA CEBP Alpha C/EBP Alpha |
| label |
CCAAT/Enhancer Binding Protein Alpha |
| Legacy_Concept_Name |
CCAAT-Enhancer_Binding_Protein_Alpha |
| OMIM_Number |
116897 |
| Preferred_Name |
CCAAT/Enhancer Binding Protein Alpha |
| prefixIRI |
C45488 |
| prefLabel |
CCAAT/Enhancer Binding Protein Alpha |
| Semantic_Type |
Biologically Active Substance Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P49715 |
| UMLS_CUI |
C0378310 |
| subClassOf |